NEW YORK (AP) — Stocks that moved substantially or traded heavily Wednesday:
AbbVie Inc. (ABBV), up $1.45 to $63.37.
AbbVie and Biogen said European Union regulators approved their once-a-month multiple sclerosis drug Zinbryta.
Nortek Inc. (NTK), up $24.01 to $86.50.
The heating and ventilation systems company agreed to be bought by Melrose Industries for $86 per share, or $1.4 billion.
Harmony Gold Mining Co. (HMY), up 22 cents to $4.32.
The price of gold continued to rise as investors looked for safe options.
United Continental Holdings Inc. (UAL), down 98 cents to $39.31.
A Credit Suisse analyst downgraded the airline and said she expects disappointing earnings and revenue.
Valero Energy Corp. (VLO), down $1.18 to $48.66.
The price of gas fell after the U.S. government said stockpiles grew last week.
Netflix Inc. (NFLX), down $3.31 to $94.60.
A Jefferies & Co. analyst downgraded the streaming video company, expecting slower U.S. subscriber growth and growing competition.
Frontier Communications Corp. (FTR), down 10 cents to $4.88.
Phone company stocks, which have climbed in recent weeks, took hefty losses on Wednesday.
Supervalu Inc. (SVU), up 40 cents to $5.00.
The grocery store operator said it will become the main wholesaler to the March Supermarkets chain in Ohio and Indiana.