Sigma-Aldrich Corporation announced its Supelco brand has released Titan UHPLC columns manufactured using the new cost-efficient, patent-pending Ecoporous silica manufacturing process. These columns are suitable for UHPLC applications in the medical chemistry, toxicology and clinical manufacturing industries as well as in academia. The columns contain the first sub-2 micrometer porous silica that is monodisperse and high-performance ( > 250,000 plates per meter), combining the advantages of solid-core and fully-porous particles. The particle is based on spherical, fully porous silica, with an ultra-narrow particle size distribution for optimum efficiency. Uniform particles are packed into column beds that are stable over a range of UHPLC flow and pressure conditions.