New data for linagliptin* show clinically meaningful efficacy similar to glimepiride but with fewer cardiovascular events
Ingelheim, Germany, June 27, 2011 – Boehringer Ingelheim and Eli Lilly and Company (NYSE: LLY) today announced Phase III study results for linagliptin (proposed trade name Trajenta® in Europe), demonstrating improved glycaemic control in adults with type 2 diabetes (T2D) whose blood glucose is not adequately maintained. In one long-term study over two years evaluating linagliptin or glimepiride when added to metformin, linagliptin was as effective at lowering blood glucose as glimepiride, as measured by haemoglobin A1C (HbA1c)** 1 but with relative weight loss (-1.4 kg vs. +1.5 kg; adjusted mean difference, -2.9 kg; p<0.0001), reduced incidence of hypoglycaemia (7.5 percent vs. 36.1 percent; p<0.0001) and fewer cardiovascular (CV) events (1.5 percent vs. 3.4 percent; Relative Risk 0.46 [0.23-0.91] p=0.02). 1 Results will be presented at the 71 st Annual American Diabetes Association (ADA) Scientific Sessions in San Diego, 24 – 28 June.
